851815-68-4Relevant academic research and scientific papers
Asymmetric synthesis of a potent azepanone-based inhibitor of the cysteine protease cathepsin K
Lee Trout, Robert E.,Marquis, Robert W.
, p. 2799 - 2801 (2007/10/03)
In this account we detail the asymmetric synthesis of 1, a potent azepanone-based inhibitor of cathepsin K (Ki = 0.16 nM), which has been shown to inhibit the production of biomarkers of bone resorption in monkeys. The key steps in the synthesi
