851847-27-3

Basic information

• Product Name: Benzoic acid, 3-(6-bromo-4-oxo-3(4H)-quinazolinyl)-4-methyl-, methyl ester
• CAS NO: 851847-27-3
• Molecular Formula: C17H13BrN2O3
• Molecular Weight: 373.206
• Mol File: 851847-27-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 3-(6-bromo-4-oxo-3(4H)-quinazolinyl)-4-methyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 3-(6-bromo-4-oxo-3(4H)-quinazolinyl)-4-methyl-, methyl ester(851847-27-3)
• EPA Substance Registry System: Benzoic acid, 3-(6-bromo-4-oxo-3(4H)-quinazolinyl)-4-methyl-, methyl ester(851847-27-3)

Safety Data

• Hazardous Substances Data: 851847-27-3(Hazardous Substances Data)

Upstream product

• 18595-18-1 3-amino-4-methyl benzoic acid methyl ester 
• 52727-57-8 5-bromo-2-aminobenzoic acid methyl ester 
• 122-51-0 orthoformic acid triethyl ester 
• 5794-88-7 5-Bromo-2-aminobenzoic acid 

Downstream Products

• 851847-28-4 methyl 4-methyl-3-[6-(4-methyl-piperazin-1-yl)-4-oxo-4H-quinazolin-3-yl]benzoate 
• 907574-57-6 methyl 3-[6-[(1E)-3-tert-butoxy-3-oxo-prop-1-en-1-yl]-4-oxo-4H-quinazolin-3-yl]-4-methylbenzoate 
• 872091-91-3 N-benzyloxycarbonyl-3-(6-bromo-4-oxoquinazolin-3(4H)-yl)-4-methylaniline 
• 872090-99-8 3-(5-amino-2-methylphenyl)-6-bromo-3H-quinazolin-4-one 
• 872090-98-7 N-[3-(6-bromo-4-oxo-4H-quinazolin-3-yl)-4-methylphenyl]-3-(1-cyano-1-methylethyl)benzamide 
• 872091-90-2 3-(6-bromo-4-oxoquinazolin-3(4H)-yl)-4-methylbenzoic acid 

Relevant articles and documents

AMIDE DERIVATIVES

The invention concerns a compound of the Formula (I) wherein m is 1-2 and each R1 is a group such as cyano, halogeno, trifluoromethyl heterocyclyl and heterocyclyloxy; R2 is trifluoromethyl or (1-6C)alkyl; R3 is hydrogen and R4 is , (1-6C)alkyl or (1-6C)alkoxy; or pharmaceutically-acceptable salts thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.

SUBSTITUTED QUINAZOLONES AS ANTI-CANCER AGENTS

The invention relates to chemical compounds of the formula (I): or pharmaceutically acceptable salts thereof, which possess B Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.