85185-39-3Relevant academic research and scientific papers
Synthesis of the Aryltetralin Lignan Skeleton via the Prins Reaction
Snider, Barry B.,Jackson, Andrew C.
, p. 1471 - 1474 (2007/10/02)
Reaction of a 1,4-diaryl-1-butene (7) with paraformaldehyde and the appropriate alkylaluminum halide generates the cation 8, via addition of formaldehyde to the double bond, which cyclizes to give the aryltetralin 9.Reaction of 1,4-diphenyl-2-butene (6a) with paraformaldehyde and methylaluminum sesquichloride gives the ene adduct 5a, which reacts further, analogously to 7, to give 4a which possesses the aryltetralin lignan skeleton.
