851857-15-3

Basic information

• Product Name: Benzene, 4-[(1,1-dimethyl-2-propynyl)oxy]-1-iodo-2-nitro-
• CAS NO: 851857-15-3
• Molecular Formula: C11H10INO3
• Molecular Weight: 331.11
• Mol File: 851857-15-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzene, 4-[(1,1-dimethyl-2-propynyl)oxy]-1-iodo-2-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 4-[(1,1-dimethyl-2-propynyl)oxy]-1-iodo-2-nitro-(851857-15-3)
• EPA Substance Registry System: Benzene, 4-[(1,1-dimethyl-2-propynyl)oxy]-1-iodo-2-nitro-(851857-15-3)

Safety Data

• Hazardous Substances Data: 851857-15-3(Hazardous Substances Data)

Upstream product

• 1111-97-3 3-chloro-3-methylbut-1-yne 
• 113305-56-9 4-iodo-3-nitrophenol 

Relevant articles and documents

SYNTHESIS OF AVRAINVILLAMIDE, STEPHACIDIN B, AND ANALOGUES THEREOF

The syntheses of the natural products, avrainvillamide and stephacidin B, are provided. The α,β-unsaturated nitrone functionality of avrainvillamide and its 3- alkylidene-3H-indole 1 -oxide core is shown to covalently and reversibly bond to heteroatom-based nucleophiles. This capability may allow these molecules to bind active site nucleophiles and may provide the basis for designing potent and selective enayme inhibitors. Both avrainvillamide and its dimer stephacidin B have been reported to exhibit antiproliferative activity, and avrainvillamide has been reported to exhibit antimicrobial activity against multi-drug resistant bacteria. Avrainvillamide has been found to target cytoskeleton-linking membrane protein (CLIMP-63) thereby preventing cells from undergoing mitosis. The invention provides syntheses of these natural products as well as analogs of these natural products and their functional cores. The compounds of the invention may be used in the treatment of diseases such as cancer, autoimmune diseases, and bacterial infection.