85197-76-8

Usage

InChI:InChI=1/C22H31FO2S2/c1-5-27-21(26-4)11-9-16-17-7-6-14-12-15(24)8-10-19(14,2)22(17,23)18(25)13-20(16,21)3/h8,10,12,16-18,25H,5-7,9,11,13H2,1-4H3/t16-,17-,18-,19-,20-,21+,22?/m0/s1

Upstream product

• 85249-12-3 (11β,17β)-11-(acetyloxy)-17-(ethylthio)-9-fluoro-17-(methylthio)androsta-1,4-dien-3-one 
• 90702-86-6 17β-ethylthio-9-fluoro-11β-hydroxy-17α-mercaptoandrosta-1,4-diene-3-one 
• 74-88-4 methyl iodide 
• 68159-86-4 (11β)-11-(Hydroxy)-9-fluoro-17-(methylthio)androsta-1,4,16-trien-3-one 

Relevant academic research and scientific papers

Selective thioketalization process, process for preparing thioenol ethers from thioketals, and process for the preparation of thioketals

A selective thioketalization process for the preparation of a thioketal from a dione where one, but not the other, keto group of the dione is α,β-unsaturated, and where selective thioketalization occurs at the keto group of the dione which is not α,β-unsaturated, comprising the step of contacting the dione with a thiol, in the presence of a protic acid catalyst which is a complex of a Lewis acid and a protic source, wherein the temperature of the reaction medium is maintained below about 25°C during the reaction. Preferably, further, (i) the acid catalyst is employed in excess and/or (ii) the thiol is employed in excess. The inventive process may be employed, for example, in the preparation of a 3-keto,17-thioketalandrostene from the corresponding 3,17-diketoandrostene. A process for the preparation of thioenolethers from thioketals, especially 3-keto,17-thioenoletherandrostenes from 3-keto,17-thioketalandrostenes, wherein the thioketal is contacted with a protic acid catalyst. A process for the preparation of thioketals, especially mixed thioketals such as mixed 3-keto,17-thioketalandrostenes, from thioenolethers, comprising the step of contacting a thioenolether with a thiol in the presence of a protic acid catalyst.

Intermediates useful in the preparation of 17,17-bis(substituted thio)androstenes

Androstenes having the formula STR1 wherein R1 hydrogen and R2 is alkyl, cycloalkyl, aryl, arylalkyl, alkylthioalkyl, alkoxyalkyl, alkanoyloxyalkyl, aroyloxyalkyl, alkoxycarobnylalkyl, carboxyalkyl, or arylalkyl, or R1 is

Antiinflammatory 17,17-bis (substituted thio) androstenes

3-Ketoandrostenes having in the 17-position the substituents R1 --S-- and R2 --S-- wherein R1 and R2 are the same or different and each is alkyl, cycloalkyl or aryl, have antiinflammatory activity.