852043-14-2Relevant academic research and scientific papers
Solvent dependent selective alkylation of a bis(sulfonamide) for the synthesis of a DNA-binding chiral polyamine
Pe?a, Carmen,Alfonso, Ignacio,Voelcker, Nicolas H.,Gotor, Vicente
, p. 2783 - 2787 (2005)
A new optically active linear polyamine has been efficiently prepared and its DNA binding abilities studied by UV melting experiments. The key step for this synthesis was the selective monoalkylation of the corresponding bis(sulfonamide). Thus, it is poss
Conformationally biased selective alkylation of trans-cyclohexane-1,2- bis(sulfonamide) assisted by solvent-tuned protecting groups: Applications to the synthesis of a large optically active polyazamacrocycle
Pena, Carmen,Alfonso, Ignacio,Gotor, Vicente
, p. 3887 - 3897 (2007/10/03)
The selective alkylation of (R,R)-cyclohexane-1,2-bis(sulfonamide) with trityl bromoalkyl ethers has been studied in detail. The major formation of either mono- or dialkylated compounds clearly depends on the right combination of protecting groups and the
