852050-29-4Relevant academic research and scientific papers
Cu/Fe/O=PPh3-catalyzed etherification for the synthesis of aryl 3-benzo[b]thienyl ethers
Mitsudo, Koichi,Asada, Takuya,Inada, Tomohiro,Kurimoto, Yuji,Mandai, Hiroki,Suga, Seiji
, p. 1044 - 1047 (2018/08/24)
Cu/Fe-cocatalyzed cross-coupling reactions between 3-bromobenzo[b]thiophene and hydroxyaryls are described herein. The combination of Cu and Fe catalysts is important for the progress of the reactions, and the use of triphenylphosphine oxide as a ligand suppresses the dehalogenation of 3-bromobenzo[b]thiophene, and promptly facilitates the reaction. The obtained aryl benzo[b]thienyl ethers can be converted to π-extended thienobenzofuran derivatives via Pd-catalyzed dehy-drogenative cyclizations.
Efficient access to 2-aryl-3-substituted benzo[b]thiophenes
David, Emilie,Perrin, Julie,Pellet-Rostaing, Stephane,Fournier Dit Chabert, Jeremie,Lemaire, Marc
, p. 3569 - 3573 (2007/10/03)
(Chemical Equation Presented) Benzo[b]thiophene derivatives are important in part because of their use as selective estrogen receptor modulators. They are usually synthesized by intramolecular cyclization. Here, we propose a method for the synthesis of 2-
