852068-82-7Relevant academic research and scientific papers
A novel synthesis of arylpyrrolo[1,2-a]pyrazinone derivatives
Wang, Fei,Wang, Jiawei,Zhang, Shoufang
, p. 574 - 582 (2004)
Some aryl-2-methyl-1-pyrrolo[1,2-a]pyrazinones were designed and prepared to study the Structure-Activity Relationships (SAR) of pyrrolo[1,2-a]pyrazinone derivatives. With methyl pyrrole-2-carboxylate as the starting material, the title compounds were prepared through N-alkylation and two novel cyclizations. Eleven aryl-2-methyl-1-pyrrolo[1,2-a]pyrazinone derivatives not previously reported in the literature are presented in this paper. Some of them show potent anti-inflammatory and analgesic activities.
