85212-83-5

Basic information

• Product Name: Propanoic acid, 2-(4-formylphenoxy)-2-methyl-
• CAS NO: 85212-83-5
• Molecular Formula: C11H12O4
• Molecular Weight: 208.214
• Mol File: 85212-83-5.mol

Chemical Properties

• CAS DataBase Reference: Propanoic acid, 2-(4-formylphenoxy)-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 2-(4-formylphenoxy)-2-methyl-(85212-83-5)
• EPA Substance Registry System: Propanoic acid, 2-(4-formylphenoxy)-2-methyl-(85212-83-5)

Safety Data

• Hazardous Substances Data: 85212-83-5(Hazardous Substances Data)

Upstream product

• 52214-84-3 2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid 
• 147032-77-7 2-<4-<(3-13C)-2,2-dichlorocyclopropyl>phenoxy>-2-methylpropanoic acid 
• 51336-35-7 α-(4-formylphenoxy)isobutyric acid ethyl ester 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 875802-13-4 2-Methyl-2-{4-[(E)-2-(5-nitro-2,6-dioxo-1,3-dipropyl-1,2,3,6-tetrahydro-pyrimidin-4-yl)-vinyl]-phenoxy}-propionic acid 
• 1393371-39-5 2-(4-(5-chlorobenzo[d]thiazol-2-yl)phenoxy)-2-methylpropanoic acid 
• 34263-73-5 2-(4-(benzo[d]thiazol-2-yl)phenoxy)-2-methylpropanoic acid 
• 1393371-38-4 2-methyl-2-(4-(5-(trifluoromethyl)benzo[d]thiazol-2-yl)phenoxy)propanoic acid 
• 480994-30-7 2-[4-(2,4-dioxo-1,3-dipropyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-phenoxy]-2-methyl-propionic acid 
• 875802-31-6 2-[4-(1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-phenoxy]-2-methyl-propionic acid 

Relevant articles and documents

2-PHENYL-3H-IMIDAZO[4,5-B]PYRIDINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY

A compound of formula (I′) or (I′′) or a pharmaceutically acceptable salt thereof. The compound is an inhibitor of mammalian kinase enzyme activity, including ROR1 tyrosine kinase activity and may be used in the treatment of disorders associated with such activity.

NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREFOR

Provided are a novel compound having skin-whitening, anti-oxidizing and PPAR activities and a medical use thereof, and the compound has skin-whitening activities for the suppression of tyrosinase, and accordingly, is useful for use in skin-whitening pharmaceutical composition or cosmetic products; has anti-oxidant activities, and accordingly, is useful for the prevention and treatment of skin-aging; and has PPAR activities, and in particular, PPARα and PPARγ activities, and accordingly, is useful for use in pharmaceutical compositions or health foods which are effective for the prevention and treatment of obesity, metabolic disease, or cardiovascular disease.

Degradation Studies under Neutral and Basic Conditions on Ciprofibrate, an Orally Active Hypolipidemic Agent Containing a (4-Alkoxyaryl)-1,1-dichlorocyclopropane Unit

The major product of degradation of ciprofibrate (1), 2-(4-(2,2-dichlorocyclopropyl)phenoxy>-2-methylpropanoic acid, in aqueous sodium hydroxide under reflux is 2--2-methylpropanoic acid (11).A further product, 2-(4-ethynylphenoxy)-2-methylpropanoic acid (12) is derived from 11 under the reaction conditions.A third degradant is identified as 2--2-methylpropanoic acid (13).Under similar conditions, but at pH 7, the products of degradation were found to be2--2-methylpropanoic acid (9) and (Z)-2--2-methylpropanoic acid (10).Treatment of 10 with aqueous sodium hydroxide under reflux afforded a mixture of products in which 11 and 12 predominated, whereas similar treatment of 9 led to compound 13 among other products.A labelling study indicates that the acid 21 derived from base treatment of 17 is labelled only at C-2 of the propanoic acid side chain; the same labelling pattern is observed in the acid 21 derived by base treatment of the labelled allylic alcohol 18.Mechanisms are suggested which may explain these observations.