852156-66-2

Upstream product

• 852156-65-1 (S)-2-benzyl-3-(tert-butyldiphenylsilanoxy)propan-1-ol 
• 852156-64-0 (S)-(2-benzyl-3-benzyloxypropoxy)-tert-butyldiphenylsilane 
• 88481-75-8 (R)-2-<(phenylmethoxy)methyl>-3-benzenepropanol 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 852156-67-3 (S)-(2-benzyl-4,4-dibromobut-3-enyloxy)-tert-butyldiphenylsilane 
• 852156-51-5 (S)-(2-benzylpent-3-ynyloxy)-tert-butyldiphenylsilane 

Relevant academic research and scientific papers

Electrostatic versus steric effects in peptidomimicry: Synthesis and secondary structure analysis of gramicidin S analogues with (E)-alkene peptide isosteres

A concise synthetic strategy was used for the first preparation of GS analogues with trisubstituted (E)-alkene peptide bond replacements. Solution and solid state conformational analysis demonstrated that the bistrifluoromethylated analogue was a superior mimic of the natural product, whereas the incorporation of methyl groups into the alkene peptide isostere led to a far greater perturbation of the secondary structure features of GS. The difference between CF3- and CH3-substitution can be explained by the superior electrostatic carbonyl group mimicry of the former function. Copyright