852204-49-0

Upstream product

• 108-24-7 acetic anhydride 
• 18620-02-5 (4-bromophenyl)magnesium bromide 
• 572-09-8 2,3,4,6-tetra-O-acetyl-D-glucopyranosyl bromide 
• 572-09-8 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide 
• 3947-62-4 2,3,4,6-tetraacetylglucose 
• 106-37-6 1.4-dibromobenzene 
• 83-87-4 D-glucose pentaacetate 

Downstream Products

• 914922-79-5 (1S)-2,3,4,6-tetra-O-acetyl-1,5-anhydro-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-D-glucitol 

Relevant academic research and scientific papers

Process For Production Of 4-Biphenylyazetidin-2-Ones

The present invention relates to processes for the production of 4-biphenylylazetidin-2-one derivatives of formula

Anti-hypercholesterolemic biaryl azetidinone compounds

This invention provides cholesterol absorption inhibitors of Formula I: and the pharmaceutically acceptable salts thereof, wherein R12 is an alkyl, alkeny or alkynyl group mono- or poly-substituted with —OH, —COOH or a combination of —OH and —COOH, and R9 contains an alkyl, alkeny or alkynyl group substituted with a heterocyclic ring, amino or sulfonyl. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating atherosclerosis and preventing atherosclerotic disease events.

1,4-DIPHENYL-3-HYDROXYALKYL-2-AZETIDINONE DERIVATIVES FOR TREATING HYPERCHOLESTROLEMIA

The invention relates to a chemical genus of 1,4-diphenyl-3-hydroxyalkyl-2-azetidinones useful for the treatment of hypercholesterolemia and related disorders, having general formula (I).

BIPHENYLAZETIDINONE CHOLESTEROL ABSORPTION INHIBITORS

The invention relates to a chemical genus of 4-biphenyl-1-phenylazetidin-2-ones useful in the treatment of hypercholesterolemia and other disorders. The compounds have the general formula (I). Pharmaceutical compositions and methods for treating cholesterol- and lipid-associated diseases are also disclosed.

DIPHENYLHETEROCYCLE CHOLESTEROL ABSORPTION INHIBITORS

Various azetidinone, pyrrolidine, imidazolidine, and oxazolidine derivatives are described, as are pharmaceutical compositions containing these compounds and methods of treatment of diseases using these compounds. Other embodiments are also described.

PHENYLAZETIDINONE DERIVATIVES

Various azetidinone derivatives are described, as are pharmaceutical compositions containing these compounds and methods of treatment of diseases using these compounds. Other embodiments are also described.

4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES

4-Biarylyl-1-phenylazetidin-2-ones useful for the treatment of hypercholesterolemia are disclosed.

4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES

4-Biarylyl-1-phenylazetidin-2-ones useful for the treatment of hypercholesterolemia are disclosed. The compounds are of a general formula (I) in which formula (II) represents an aryl or heteroaryl residue, Ar represents an aryl residue; U is a two to six atom chain; and the R’s represent substituents.