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Usage

Uses

Used in Organic Synthesis:
3-(1H-PYRAZOL-1-YL)BENZALDEHYDE is used as a key building block for the synthesis of a variety of biologically active molecules. Its presence in organic synthesis is crucial for the development of complex organic compounds that can exhibit a range of biological activities.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 3-(1H-PYRAZOL-1-YL)BENZALDEHYDE is utilized as a reagent for the preparation of pharmaceuticals. Its unique structure allows it to be a part of drug discovery processes, where it can be incorporated into new molecules with potential therapeutic applications.
Used in Pharmaceutical Preparation:
3-(1H-PYRAZOL-1-YL)BENZALDEHYDE is used as a reagent in the preparation of pharmaceuticals, indicating its importance in the development of new drugs. Its role in this industry is to contribute to the synthesis of compounds that can be used for treating various medical conditions.
Used in Agrochemical Production:
3-(1H-PYRAZOL-1-YL)BENZALDEHYDE also finds application in the agrochemical industry, where it is used in the synthesis of various agrochemicals. Its use in this sector highlights its versatility and the broad range of industries that can benefit from its unique properties.
Used in the Synthesis of Fine Chemicals:
3-(1H-PYRAZOL-1-YL)BENZALDEHYDE is employed in the preparation of fine chemicals, which are high-purity chemicals used in various applications, including research, pharmaceuticals, and other specialized industries. Its role in this area underscores its value in creating high-quality chemical products.

InChI:InChI=1/C10H8N2O/c13-8-9-3-1-4-10(7-9)12-6-2-5-11-12/h1-8H

Upstream product

• 87199-16-4 3-Formylphenylboronic acid 
• 288-13-1 NH-pyrazole 
• 3132-99-8 m-bromobenzoic aldehyde 
• 75-25-2 Bromoform 
• 1126-00-7 1-phenylpyrazole 

Relevant academic research and scientific papers

Ruthenium-Catalyzed meta-Selective CAr-H Bond Formylation of Arenes

The meta-CAr-H bond formylation of arenes has been achieved using CHBr3 as a formyl source in the presence of [Ru(p-cym)(OAc)2] as a catalyst. This method provides efficient access to the preparation of various meta-substituted aromatic compounds, such as alcohols, ethers, amines, nitriles, alkenes, halogens, carboxylic acids, and their derivatives, through transformation of the versatile formyl group. Furthermore, mechanistic studies show that the key active species is a pentagonal ruthenacycle complex.

Cu(II)-catalyzed C-N coupling of (hetero)aryl halides and N-Nucleophiles promoted by α-benzoin oxime

We first reported the new application of a translate metal chelating ligand α-benzoin oxime for improving Cu-catalyzed C-N coupling reactions. The system could catalyse coupling reactions of (hetero)aryl halides with a wide of nucleophiles (e.g., azoles, piperidine, pyrrolidine and amino acids) in moderate to excellent yields. The protocol allows rapid access to the most common scaαolds found in FDA-approved pharmaceuticals.

L -(-) -Quebrachitol as a Ligand for Selective Copper(0)-Catalyzed N-Arylation of Nitrogen-Containing Heterocycles

l-(-)-Quebrachitol (QCT) has been found as a ligand of copper powder for selective N-arylation of nitrogen-containing heterocycles with aryl halides. Furthermore, another potential catalytic system (copper powder/QCT/t-BuOK) was successfully adapted to unactivated aryl chlorides.

α-d-Galacturonic Acid as Natural Ligand for Selective Copper-Catalyzed N-Arylation of N-Containing Heterocycles

The first application of α-d-galacturonic acid hydrate (GalA) is reported here, as a potential O-donor ligand. The C-N couplings of N-heterocycles with aryl halides or arylboronic acids could be readily conducted and exhibited good functional group tolerance with characters of selectivity. These N-Arylazoles allow rapid access to several pharmaceutical intermediates and can be easily transformed into a variety of other interesting scaffolds as well.

BROAD SPECTRUM ANTIVIRAL COMPOSITIONS AND METHODS

Novel thiazole- and isoquinoline- containing compounds are presented that are useful for treating and/or preventing broad-spectrum viral infections. Methods of treating and/or preventing broad-specturm viral infections are also presented. These compounds have shown inhibitio of HCMV, influenza viruses, Zika virus, BK Virus and RSV replication in cell-based assays.

ANTI-HCMV COMPOSITIONS AND METHODS

Novel compounds useful for treating and/or preventing HCMV infections are provided.

Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors

Sant-75 is a newly identified potent inhibitor of the hedgehog pathway. We designed a diversity-oriented synthesis program, and synthesized a series of Sant-75 analogues, which lays the foundation for further investigation of the structure-activity relationship of this important class of hedgehog-pathway inhibitors.

6-O-acyl ketolide antibacterials

6-O-Acyl ketolide antibacterials of the formula: wherein R1, R2, R3, R4, W, X, X′, Y, and Y′ are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.

6-O-carbamoyl ketolide antibacterials

6-O-Carbamoyl ketolide antibacterials of the formula: wherein R1, R2, R3, R4, R5, R6, X, X′, Y, and Y′ are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.

6-0-carbamoyl ketolide antibacterials

6-O-Carbamoyl ketolide antibacterials of the formula: wherein R1, R2, R3, R4, R5, R6, X, X′, Y, and Y′ are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.