852227-92-0

Basic information

• Product Name: 3-(1H-PYRAZOL-1-YL)BENZALDEHYDE
• Synonyms: 3-PYRAZOL-1-YL-BENZALDEHYDE;3-(1H-PYRAZOL-1-YL)BENZALDEHYDE;CHEMBRDG-BB 4004821;3-(1H-pyrazol-1-yl)benzenecarbaldehyde;3-(1H-pyrazol-1-yl)benzaldehyde(SALTDATA: FREE)
• CAS NO: 852227-92-0
• Molecular Formula: C10H8N2O
• Molecular Weight: 172.18
• Mol File: 852227-92-0.mol
• Article Data: 10

Chemical Properties

• Melting Point: 38-39
• Boiling Point: 315.5 °C at 760 mmHg
• Flash Point: 144.6 °C
• Appearance: /
• Density: 1.15 g/cm³
• Vapor Pressure: 0.000436mmHg at 25°C
• Refractive Index: 1.604
• PKA: -0.20±0.12(Predicted)
• CAS DataBase Reference: 3-(1H-PYRAZOL-1-YL)BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1H-PYRAZOL-1-YL)BENZALDEHYDE(852227-92-0)
• EPA Substance Registry System: 3-(1H-PYRAZOL-1-YL)BENZALDEHYDE(852227-92-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 852227-92-0(Hazardous Substances Data)

Usage

General Description

3-(1H-pyrazol-1-yl)benzaldehyde is a chemical compound with the molecular formula C10H8N2O. It is a yellow solid with a molecular weight of 172.18 g/mol. 3-(1H-PYRAZOL-1-YL)BENZALDEHYDE is often used in organic synthesis and medicinal chemistry as a building block for the synthesis of various biologically active molecules. It is also used as a reagent in the preparation of pharmaceuticals, agrochemicals, and other fine chemicals. The presence of the pyrazole ring in this compound makes it an important scaffold for the development of new drug candidates with potential therapeutic applications. Its unique structure and reactivity make 3-(1H-pyrazol-1-yl)benzaldehyde a valuable compound in the field of medicinal chemistry and drug discovery.

InChI:InChI=1/C10H8N2O/c13-8-9-3-1-4-10(7-9)12-6-2-5-11-12/h1-8H

Upstream product

• 75-25-2 Bromoform 
• 1126-00-7 1-phenylpyrazole 
• 288-13-1 NH-pyrazole 
• 3132-99-8 m-bromobenzoic aldehyde 
• 87199-16-4 3-Formylphenylboronic acid 

Relevant articles and documents

Ruthenium-Catalyzed meta-Selective CAr-H Bond Formylation of Arenes

The meta-CAr-H bond formylation of arenes has been achieved using CHBr3 as a formyl source in the presence of [Ru(p-cym)(OAc)2] as a catalyst. This method provides efficient access to the preparation of various meta-substituted aromatic compounds, such as alcohols, ethers, amines, nitriles, alkenes, halogens, carboxylic acids, and their derivatives, through transformation of the versatile formyl group. Furthermore, mechanistic studies show that the key active species is a pentagonal ruthenacycle complex.

L -(-) -Quebrachitol as a Ligand for Selective Copper(0)-Catalyzed N-Arylation of Nitrogen-Containing Heterocycles

l-(-)-Quebrachitol (QCT) has been found as a ligand of copper powder for selective N-arylation of nitrogen-containing heterocycles with aryl halides. Furthermore, another potential catalytic system (copper powder/QCT/t-BuOK) was successfully adapted to unactivated aryl chlorides.

BROAD SPECTRUM ANTIVIRAL COMPOSITIONS AND METHODS

Novel thiazole- and isoquinoline- containing compounds are presented that are useful for treating and/or preventing broad-spectrum viral infections. Methods of treating and/or preventing broad-specturm viral infections are also presented. These compounds have shown inhibitio of HCMV, influenza viruses, Zika virus, BK Virus and RSV replication in cell-based assays.