852285-89-3Relevant academic research and scientific papers
Visible-light-induced regioselective synthesis of polyheteroaromatic compounds
Chatterjee, Tanmay,Choi, Myung Gil,Kim, Jun,Chang, Suk-Kyu,Cho, Eun Jin
supporting information, p. 4203 - 4206 (2016/03/19)
A method for visible-light-induced synthesis of polyheteroaromatics from 2-heteroaryl-substituted anilines and heteroarylalkynes was developed. The process, which uses fac-Ir(ppy)3 as the photocatalyst and tBuONO as the diazotization reagent, is highly regioselective.
Synthesis and anti-tubercular activity of fused thieno-/furo-quinoline compounds
Akula, Mahesh,Yogeeswari,Sriram,Jha, Mukund,Bhattacharya, Anupam
, p. 46073 - 46080 (2016/06/09)
A simple route for preparation of 4-substituted thieno/furo[2,3-c]quinoline compounds is reported in this paper. These compounds were synthesized by using Suzuki coupling between appropriate boronic acid and 2-iodoaniline, followed by reaction with diverse aldehydes in the presence of a catalytic amount of FeCl3. Naphthyridine analogues were also prepared in order to demonstrate the efficacy of the developed method. Further anti-tubercular activity screening of the molecules was undertaken, wherein compounds bearing a fused furo[2,3-c][1,8]naphthyridine skeleton displayed highest activity. The best MIC (minimum inhibitory concentration) value of 5.6 μmol was obtained for 4-(4-methoxyphenyl)furo[2,3-c][1,8]naphthyridine, which is found to be superior to the existing first line anti-tubercular drug ethambutol (7.6 μmol).
Inhibitors of C-FMS kinase
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, (2008/06/13)
The invention relates to compounds of Formula I: wherein A is phenyl, naphthyl or biphenyl, each of which may be optionally substituted with one or more of -C1-6 alkyl, amino, aminoalkyl, hydroxyalkyl, alkoxyalkyl, sulfonamidoalkyl, guanidinoal
