852288-18-7

Usage

Chemical Properties

White powder

Upstream product

• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 77-76-9 2,2-dimethoxy-propane 
• 137018-93-0 N-(9-fluorenylmethyloxycarbonyl)-3,4-dihydroxy-L-phenylalanine 
• 1220710-11-1 methyl (2S)-3-(2,2-dimethyl-1,3-benzodioxol-5-yl)-2-(2,2,2-trifluoroacetamido)propanoate 
• 297144-74-2 methyl (2S)-3-(3,4-dihydroxyphenyl)-2-(2,2,2-trifluoroacetamido)propanoate 
• 1064196-08-2 L-(3,4-acetonide-dihydroxy)phenylalanine methyl ester 
• 156624-80-5 Phth-DOPA(acetonide)-OMe 
• 1064196-07-1 N-phthalimide-3,4-dihydroxy-L-phenylalanine methyl ester 
• 297144-73-1 (2S)-3-(3,4-dihydroxyphenyl)-2-(2,2,2-trifluoroacetamido)propanoic acid 
• 59-92-7 levodopa 

Downstream Products

• 59-92-7 levodopa 

Relevant academic research and scientific papers

Medical intermediate compound and synthesis method thereof

The invention provides a medical intermediate compound and a synthesis method thereof and belongs to the field of medicine synthesis. The compound has the structural formula shown in the description,wherein the substance shown in the description is obtain

Method of synthesizing acetonide-protected catechol-containing compounds and intermediates produced therein

The inventors disclose here a novel, facile approach to the synthesis of acetonide-protected catechol-containing compounds having at least one amine group. In specific embodiments, the invention provides novel methods of synthesizing 3,4-dihydroxyphenylalanine (H-DOPA(acetonide)-OH (6)), Fmoc-protected H-DOPA(acetonide)-OH (Fmoc-DOPA(acetonide)-OH (7)), Fmoc-protected dopamine (Fmoc-dopamine(acetonide) (10)), TFA-protected dopamine (TFA-dopamine(acetonide) (13)) and acetonide-protected 4-(2-aminoethyl)benzene-1,2-diol (acetonide-protected dopamine (14)).

Method of Synthesizing Acetonide-Protected Catechol-Containing Compounds and Intermediates Produced Therein

The inventors disclose here a novel, facile approach to the synthesis of acetonide-protected catechol-containing compounds having at least one amine group. In specific embodiments, the invention provides novel methods of synthesizing 3,4-dihydroxyphenylalanine (H-DOPA(acetonide)-OH (6)), Fmoc-protected H-DOPA(acetonide)-OH (Fmoc-DOPA(acetonide)-OH (7)), Fmoc-protected dopamine (Fmoc-dopamine(acetonide) (10)), TFA-protected dopamine (TFA-dopamine(acetonide) (13)) and acetonide-protected 4-(2-aminoethyl)benzene-1,2-diol (acetonide-protected dopamine (14)).

Convenient synthesis of acetonide-protected 3,4-dihydroxyphenylalanine (DOPA) for Fmoc solid-phase peptide synthesis

We report a facile approach to the synthesis of acetonide and Fmoc-protected 3,4-dihydroxyphenylalanine (DOPA), Fmoc-DOPA(acetonide)-OH. By protecting the amino group of DOPA with a phthaloyl group and the carboxyl group as a methyl ester, acetonide protection of the catechol of DOPA derivative was realized in the presence of p-toluenesulfonic acid. Following removal of protecting groups, the intermediate was converted to Fmoc-DOPA(acetonide)-OH, which was successfully incorporated into a short DOPA-containing peptide, derived from marine tubeworm cement proteins Pc1 and Pc2.