852292-38-7

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 61272-76-2 4-fluoro-2-iodoaniline 
• 852292-27-4 N-(4-fluoro-2-iodophenyl)-4-methylbenzenesulfonamide 
• 107-19-7 propargyl alcohol 

Downstream Products

• 38470-26-7 6-fluoro-2,3-dihydroquinolin-4(1H)-one 
• 852292-62-7 2-[3-[5-Fluoro-2-(toluene-4-sulfonylamino)-phenyl]-prop-2-yn-(E)-ylidene]-succinic acid 1-ethyl ester 
• 852292-50-3 N-[4-fluoro-2-(3-oxo-prop-1-ynyl)-phenyl]-4-methyl-benzenesulfonamide 

Relevant academic research and scientific papers

Superacid-catalyzed tandem Meyer–Schuster rearrangement/intramolecular hydroamination of o-anilinopropargyl alcohols for the synthesis of 2,3-dihydro-4(1H)-quinolones

A TfOH-catalyzed synthesis of 2,3-dihydro-4(1H)-quinolones from o-anilinopropargyl alcohols was developed. Studies of N-protecting groups and substituents in phenyl rings showed that diverse groups could be applied. By controlling the catalyst loading, o-anilinopropargyl alcohols underwent the expected transformation smoothly to produce N-protected or N-deprotected 2,3-dihydro-4 (1H)-quinolones in good yields. This transformation probably involved a tandem Meyer–Schuster rearrangement/intramolecular hydroamination reaction process.

A new preparative route to substituted carbazoles by benzannulation

A new regioselective pathway to substituted carbazole derivatives is described here. According to this procedure substituted 2-alkoxycarbonyl-4- acetoxy-9-(p-toluenesulfonyl) carbazoles are obtained by treatment of substituted 6-[2-(p-toluenesulfonyl-amin