85230-38-2Relevant academic research and scientific papers
Highly enantioselective synthesis of chiral cyclic amino alcohols and conhydrine by ruthenium-catalyzed asymmetric hydrogenation
Liu, Sheng,Xie, Jian-Hua,Li, Wei,Kong, Wei-Ling,Wang, Li-Xin,Zhou, Qi-Lin
supporting information; experimental part, p. 4994 - 4997 (2009/12/28)
A highly efficient enantio- and diastereoselective synthesis of chiral cis-β-N-alkyl/arylamino cyclic alcohols has been realized by asymmetric hydrogenation of racemic α-amino cyclic ketones via DKR catalyzed by [RuCl2((S)-Xyl-SDP)((R,R)-DPEN)]. The enantioselectivities of the reaction were up to 99.9% ee with 99:1 cis-selectivities. A practical catalytic asymmetric synthesis of all four isomers of conhydrine was also developed.
On the Reaction of 2-Aminopyridines with alpha-Halocarbonyl Compounds
Elliott, Arthur J.,Guzik, Henry,Soler, Jose R.
, p. 1437 - 1440 (2007/10/02)
The reactions of 6-substituted-2-aminopyridines with bromoacetone and 3-bromo-2-butanone have been investigated.In contrast to bromoacetone which gives a high yield of the imidazopyridine, bromobutanone also produces significant amounts of material
