852358-79-3 Usage
General Description
1(2H)-Pyridinecarboxylic acid, 4-(aminomethyl)-3,6-dihydro-, ethyl ester, also known as ethyl 3,6-dihydro-4-aminomethyl-2(1)H-pyridinecarboxylate, is a chemical compound with potential biological and pharmacological properties. It is an ethyl ester derivative of nipecotic acid, which is a GABA (gamma-aminobutyric acid) reuptake inhibitor. 1(2H)-Pyridinecarboxylic acid, 4-(aminomethyl)-3,6-dihydro-, ethyl ester has been studied for its potential use in treating neurological disorders such as epilepsy and anxiety. It has also been investigated for its potential as an antimicrobial agent. The ethyl ester form of nipecotic acid is being researched for its ability to cross the blood-brain barrier, making it a potential candidate for central nervous system drug delivery. Further research is ongoing to explore the full therapeutic potential of this compound.
Check Digit Verification of cas no
The CAS Registry Mumber 852358-79-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,2,3,5 and 8 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 852358-79:
(8*8)+(7*5)+(6*2)+(5*3)+(4*5)+(3*8)+(2*7)+(1*9)=193
193 % 10 = 3
So 852358-79-3 is a valid CAS Registry Number.
852358-79-3Relevant articles and documents
Synthesis and pharmacological evaluation of benzamide derivatives as selective 5-HT4 receptor agonists
Sonda, Shuji,Kawahara, Toshio,Katayama, Kenichi,Sato, Noriko,Asano, Kiyoshi
, p. 3295 - 3308 (2007/10/03)
It is thought that selective 5-HT4 receptor agonists-such as 4-amino-5-chloro-2-methoxy-N-[1-(6-oxo-6-phenylhexyl)piperidin-4-ylmethyl] benzamide (2)-have the ability to enhance both upper and lower gastrointestinal motility without any significant adverse effects. Modification of 2 was performed. Variation of the piperidin-4-ylmethyl moiety of 2 led to a decrease in the binding affinity for the 5-HT4 receptor. Following conversion of the carbonyl group on the benzoyl part to a hydroxyl or sulfoxide group, the binding affinity for the 5-HT4 receptor was retained although the effect on defecation was reduced. Many of the 4-amino-5-chloro-2-methoxy-N- (piperidin-4-ylmethyl)benzamides that had a ether or sulfide moiety in the side-chain part at the 1-position of the piperidine exhibited high affinity for the 5-HT4 receptor. Among these, phenylthio 41c and benzylthio derivative 44 were selective 5-HT4 receptor agonists, and had a similar effect on defecation to compound 2.
