85236-99-3Relevant academic research and scientific papers
An Expedient Synthetic Approach to the Physostigmine Alkaloids via Intramolecular Formamidine Ylide Cycloadditions
Smith, Richard,Livinghouse, Tom
, p. 1554 - 1555 (1983)
New approaches for the direct generation of several highly reactive imidate methylides are described that rely upon acyl fluoride mediated desylilation.The utility of this methodology has been demonstrated in a stereospecific synthesis of dl-eserethole (4
Alkaloid synthesis via the intramolecular imidate methylide 1,3-dipolar cycloaddition reaction
Smith, Richard,Livinghouse, Tom
, p. 3559 - 3568 (2007/10/02)
A concise synthesis for the neurotoxic physostigmine alkaloid d,l-eserethole is described which relys upon an intramolecular cycloaddition reaction involving a "non-stabilized" imidate methylide and an unactivated alkene. The facility of this cyclization
