852361-91-2Relevant academic research and scientific papers
The synthesis of (9S)-9-alkyl-9-hydroxyerythromycin a derivatives and their ketolides
Grant, Eugene B.,Weiss, Jesse M.,Branum, Shawn,Hayden, Stuart,Johnson, Sigmond,Guiadeen, Deodialsingh,Murray, William V.,Macielag, Mark J.
, p. 2731 - 2735 (2007/10/03)
A short, concise synthesis of a novel series of (9S)-9-alkyl-9- hydroxyerythromycin A derivatives and their corresponding ketolides, is described. The key chemical transformation is a stereoselective addition of organomagnesium or organolithium agents to the 9-position of the suitably protected macrolide templates 8 and 13.
