852362-24-4

Basic information

• Product Name: PYRIMIDIN-4-YLBORONIC ACID
• Synonyms: PYRIMIDIN-4-YLBORONIC ACID;Pyrimidine-4-boronic acid;4-Boronopyrimidine;PyriMidin-4-boronic acid;Boronic acid,B-4-pyriMidinyl-;Pyrimidine-3-boronic acid
• CAS NO: 852362-24-4
• Molecular Formula: C4H5BN2O2
• Molecular Weight: 123.91
• Product Categories: Pyridines
• Mol File: 852362-24-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 334.7 °C at 760 mmHg
• Flash Point: 156.2 °C
• Appearance: /
• Density: 1.33
• Vapor Pressure: 4.95E-05mmHg at 25°C
• Refractive Index: 1.534
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 6.86±0.53(Predicted)
• CAS DataBase Reference: PYRIMIDIN-4-YLBORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: PYRIMIDIN-4-YLBORONIC ACID(852362-24-4)
• EPA Substance Registry System: PYRIMIDIN-4-YLBORONIC ACID(852362-24-4)

Safety Data

• Hazardous Substances Data: 852362-24-4(Hazardous Substances Data)

Usage

Uses

Pyrimidin-4-ylboronic Acid is an intermediate used to prepare aldosterone synthase inhibiting pyrimidinylnaphthalenes via Suzuki cross-coupling reactions. It is also used in the synthesis of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine as a potent, orally active Src kinase inhibitor with antitumor activity.

InChI:InChI=1/C4H5BN2O2/c8-5(9)4-1-2-6-3-7-4/h1-3,8-9H