85237-02-1Relevant academic research and scientific papers
The Direct Generation of N-Acyl Formimidate Methylides. An Efficient Approach to the Synthesis of Pyrrolidine Derivatives
Livinghouse, Tom,Smith, Richard
, p. 210 - 211 (2007/10/02)
The reaction of silyl-formamidines and silyl-thioformimidates with acyl fluorides gives N-acyl imidate methylides which have been successfully trapped with several dipolarophiles to afford pyrrolidine derivatives in high yields.
An Expedient Synthetic Approach to the Physostigmine Alkaloids via Intramolecular Formamidine Ylide Cycloadditions
Smith, Richard,Livinghouse, Tom
, p. 1554 - 1555 (2007/10/02)
New approaches for the direct generation of several highly reactive imidate methylides are described that rely upon acyl fluoride mediated desylilation.The utility of this methodology has been demonstrated in a stereospecific synthesis of dl-eserethole (4
