85237-06-5Relevant academic research and scientific papers
Alkaloid synthesis via the intramolecular imidate methylide 1,3-dipolar cycloaddition reaction
Smith, Richard,Livinghouse, Tom
, p. 3559 - 3568 (2007/10/02)
A concise synthesis for the neurotoxic physostigmine alkaloid d,l-eserethole is described which relys upon an intramolecular cycloaddition reaction involving a "non-stabilized" imidate methylide and an unactivated alkene. The facility of this cyclization
An Expedient Synthetic Approach to the Physostigmine Alkaloids via Intramolecular Formamidine Ylide Cycloadditions
Smith, Richard,Livinghouse, Tom
, p. 1554 - 1555 (2007/10/02)
New approaches for the direct generation of several highly reactive imidate methylides are described that rely upon acyl fluoride mediated desylilation.The utility of this methodology has been demonstrated in a stereospecific synthesis of dl-eserethole (4
