85237-63-4 Usage
Chemical structure
A compound consisting of a pyridine ring (a six-membered aromatic ring with one nitrogen atom) and a piperidine ring (a six-membered ring with one nitrogen atom) connected at the 2nd and 4th positions, with a methyl group attached to the piperidine ring.
Derivative of piperidine and pyridine
2-(1-methylpiperidin-4-yl)pyridine is a modified version of the parent compounds piperidine and pyridine.
Common use in synthesis
The compound is commonly used in the synthesis of pharmaceutical and agricultural products.
Nicotine receptor agonist
2-(1-methylpiperidin-4-yl)pyridine binds to and activates nicotine receptors in the body.
Potential use in treatment of nicotine addiction
The compound has been studied for its potential to help individuals quit smoking or using tobacco products.
Insecticidal properties
2-(1-methylpiperidin-4-yl)pyridine has been investigated for its ability to kill or repel insects, making it a potential insecticide.
Versatile compound
Due to its multiple potential applications, 2-(1-methylpiperidin-4-yl)pyridine is a versatile compound with uses in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 85237-63-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,5,2,3 and 7 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 85237-63:
(7*8)+(6*5)+(5*2)+(4*3)+(3*7)+(2*6)+(1*3)=144
144 % 10 = 4
So 85237-63-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H16N2/c1-13-8-5-10(6-9-13)11-4-2-3-7-12-11/h2-4,7,10H,5-6,8-9H2,1H3
85237-63-4Relevant academic research and scientific papers
Structure-affinity relationships of a unique nicotinic ligand: N1-dimethyl-N4-phenylpiperazinium iodide (DMPP)
Romanelli,Manetti,Scapecchi,Borea,Dei,Bartolini,Ghelardini,Gualtieri,Guandalini,Varani
, p. 3946 - 3955 (2007/10/03)
DMPP is a well-known nicotinic agonist that does not fit any proposed pharmacophore for nicotinic binding and represents a unique ligand among the hundreds of nicotinic agonists studied in the past decades. A systematic modulation of the chemical structure of DMPP, aimed to establish its structure-affinity relationships, is reported. The research has allowed to identify molecules such as 11c, 13c, 14c, and 28c, with affinities for α4β2 receptors in the low nanomolar range, some 2 orders of magnitude lower than the lead compound. The agonistic properties of the most interesting compounds have been assessed by measuring their analgesic activity on mice (hot-plate test). Another result of the research was the identification of DMPP analogues, such as 3a (Ki = 90 nM) and 14b (Ki = 180 nM), that maintain affinity for the central nicotinic receptor when the ammonium function is changed into an aminic one and are therefore possible leads for drug development in neurodegenerative diseases.
