85237-67-8

Basic information

• Product Name: 3-methyl-2-phenylpiperidine
• Synonyms: 3-methyl-2-phenylpiperidine;Einecs 286-428-0
• CAS NO: 85237-67-8
• Molecular Formula: C₁₂H₁₇N
• Molecular Weight: 175.27008
• EINECS: 286-428-0
• Mol File: 85237-67-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 266.8°C at 760 mmHg
• Flash Point: 115.6°C
• Appearance: /
• Density: 0.938g/cm³
• Vapor Pressure: 0.00845mmHg at 25°C
• Refractive Index: 1.507
• CAS DataBase Reference: 3-methyl-2-phenylpiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-2-phenylpiperidine(85237-67-8)
• EPA Substance Registry System: 3-methyl-2-phenylpiperidine(85237-67-8)

Safety Data

• Hazardous Substances Data: 85237-67-8(Hazardous Substances Data)

Usage

General Description

3-methyl-2-phenylpiperidine is a chemical compound belonging to the piperidine class of organic compounds. It is a cyclic amine with a piperidine ring containing a methyl group at the third position and a phenyl group at the second position. 3-methyl-2-phenylpiperidine has been studied for its potential pharmacological properties, including its use as a precursor in the synthesis of various pharmaceuticals and as a building block in organic synthesis. Its unique structure and properties make it a valuable compound for research and industrial applications, particularly in the development of new drugs and chemicals.

InChI:InChI=1/C12H17N/c1-10-6-5-9-13-12(10)11-7-3-2-4-8-11/h2-4,7-8,10,12-13H,5-6,9H2,1H3

Upstream product

• 89229-73-2 acide methyl-4 oxo-5 phenyl-5 pentanoique 

Relevant articles and documents

Enzyme Cascades in Whole Cells for the Synthesis of Chiral Cyclic Amines

The increasing diversity of reactions mediated by biocatalysts has led to development of multistep in vitro enzyme cascades, taking advantage of generally compatible reaction conditions. The construction of pathways within single whole cell systems is much less explored, yet has many advantages. Herein we report the generation of a successful whole cell de novo enzyme cascade for the diastereoselective and/or enantioselective conversion of simple, linear keto acids into valuable cyclic amine products. The pathway starts with carboxylic acid reduction that triggers a transamination, imine formation, and subsequent imine reduction. Construction and optimization of the system was achieved by standard genetic manipulation and the cascade required only starting material, amine donor, and whole cell catalyst with cofactors provided internally by glucose metabolism. A panel of synthetic keto acids provided access to piperidines in high conversions (up to 93%) and enantiomeric excess (up to 93%).