852380-52-0

Upstream product

• 852380-46-2 (1R,3R,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-1-hydroxy-4-methylene-6-oxa-bicyclo[3.2.1]octan-7-one 
• 766529-94-6 (1R,3R,5R)-3-[(tert-butyldimethylsilyl)oxy]-1-hydroxy-6-oxa-bicyclo[3.2.1]octane-4,7-dione 
• 665-27-0 1,5-quinide 
• 163217-18-3 (1R,3R,4S,5R)-3-[(tert-butyldimethylsilyl)oxy]-1,4-dihydroxy-6-oxa-bicyclo[3.2.1]octan-7-one 
• 77-95-2 D-(-)-quinic acid 
• 852380-56-4 [3,5-bis-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-4-methylene-cyclohexyl]-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrol-2-yl]-methanone 
• 852380-68-8 [3-(tert-butyl-dimethyl-silanyloxy)-1,5-dihydroxy-4-methylene-cyclohexyl]-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrol-2-yl]-methanone 
• 852380-57-5 [3-(tert-butyl-dimethyl-silanyloxy)-1,5-dihydroxy-4-methylene-cyclohexyl]-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrol-2-yl]-methanone 
• 852380-55-3 7-(tert-butyl-dimethyl-silanyloxy)-6-methylene-1-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrole-2-carbonyl]-2,4-dioxa-bicyclo[3.3.1]nonan-3-one 

Downstream Products

• 852380-97-3 (1S,8S,11S)-3-{5-[6-Bromo-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-6-methoxy-pyrazin-2-yl}-8-methoxy-11-methyl-5-(2-trimethylsilanyl-ethoxymethyl)-5-aza-tricyclo[6.3.1.0^2,6]dodeca-2⁽⁶⁾,3-diene-7,10-dione 

Relevant academic research and scientific papers

Development of an enantiodivergent strategy for the total synthesis of (+)- and (-)-dragmacidin f from a single enantiomer of quinic acid

An enantiodivergent strategy for the total chemical synthesis of both (+)- and (-)-dragmacidin F beginning from a single enantiomer of quinic acid has been developed and successfully implemented. Although unique, the synthetic routes to these antipodes share a number of key features, including novel reductive isomerization reactions, Pd(II)-mediated oxidative carbocyclization reactions, halogen-selective Suzuki couplings, and high-yielding late-stage Neber rearrangements.

Heterogeneous reductive isomerization reaction using catalytic Pd/C and H2

(Chemical Equation Presented) A highly selective catalytic reductive isomerization reaction is described. The extremely mild and neutral reaction conditions (10% Pd/C, H2, and MeOH at 0°C) tolerate a wide range of functional groups and generall