852382-18-4Relevant academic research and scientific papers
A general carbometalation, three component coupling strategy for the synthesis of α,β-unsaturated γ-sultines including thio-rofecoxib, a selective COX-2 inhibitor
Smil, David V.,Souza, Fabio E.S.,Fallis, Alex G.
, p. 2057 - 2060 (2005)
Magnesium mediated carbometalation (Grignard addition) to appropriate propargyl alcohols to synthesize a cross-section of variably substituted α,β-unsaturated γ-sultines is described. Thio-rofecoxib, a selective COX-2 inhibitor (12), is synthesized by thi
