852395-55-2

Upstream product

• 1034620-35-3 1,3-di-O-(2,3,4,6-tetra-O-benzyl-α-D-mannopyranosyl)-1-O-(2-triisopropylsilane)-sn-glycerol 
• 1273157-04-2 1,3-bis-(2,3,4,5-tetra-O-benzyl-α-D-mannopyranosyl)-2-O-(4-methoxybenzyl)glycerol 

Downstream Products

• 1034620-37-5 1,3-di-O-(2,3,4,6-tetra-O-benzyl-α-D-mannopyranosyl)-1-O-(1-O-hexadecanoyl-2-O-hexadecyl-sn-glycero-3-benzyIphosphoryl)glycerol 
• 852395-58-5 2-O-(1,2-di-O-stearoyl-sn-glycero-3-phosphoryl)-1,3-bis-O-(2,3,4,6-tetra-O-benzyl-α-D-mannopyranosyl)glycerol triethylammonium salt 

Relevant academic research and scientific papers

A PIM2 analogue suppresses allergic airway disease

Two approaches for the synthesis of a phosphatidylinositol dimannoside (PIM2) analogue 4 that mimics the suppressive activity of natural PIMs and also synthetic PIM2 have been developed. This analogue, where the inositol core was rep

ANALOGUES OF PHOSPHATIDYLINOSITOL MANNOSIDES

The invention relates to compounds which are immunomodulatory compounds and, in particular, can induce IL-12 secretion. The invention also relates to compositions containing the compounds, precursors, and prodrugs of these compounds, use of these compounds as adjuvants in combination with vaccines, and use of these compounds for treatment of diseases or conditions relating to infection, atopic disorders, or cancer.

SYNTHETIC MOLECULES HAVING IMMUNE ACTIVITY

The present invention is directed to synthetic molecules having biological activity similar to PIM (acyl glycerol phosphatidylinositol manno-oligosaccharide) activity, for use in the treatment and prevention of inflammatory or immune cell mediated diseases or disorders.