852435-04-2Relevant academic research and scientific papers
Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines: Key precursors to potent c-Met inhibitors
Wang, Yuanxiang,Ai, Jing,Liu, Gang,Geng, Meiyu,Zhang, Ao
, p. 5930 - 5933 (2011)
An effective one-pot synthesis of quinolines bearing diverse C3-piperazinyl functions was developed by using a modified Friedlaender's protocol. The method not only enables the synthesis of our early reported c-Met inhibitor on a large scale, but also provides a way to generate novel multi-substituted quinolines for further structure-activity relationship (SAR) study.
