852471-18-2

Upstream product

• 4315-07-5 4-(trifluoromethoxy)phenylacetic acid 
• 95299-18-6 methyl 2-(4-(trifluoromethoxy)phenyl)acetate 
• 1195951-67-7 C₁₀H₇F₃N₂O₂ 
• 100-51-6 benzyl alcohol 
• 852471-19-3 1-(toluene-4-sulfonyl)-3-benzyloxy-4-(4-trifluoromethoxyphenyl)-1H-pyrazole 

Downstream Products

• 1195951-69-9 C₂₆H₂₀F₆N₂O₃ 
• 1195951-70-2 C₁₉H₁₄F₆N₂O₃ 
• 1195951-72-4 C₂₆H₁₈F₆N₂O₅ 
• 1195951-71-3 C₃₀H₂₆F₆N₂O₅ 
• 1195951-75-7 C₂₉H₂₃F₆N₃O₆ 
• 1195951-73-5 C₃₃H₃₁F₆N₃O₆ 

Relevant academic research and scientific papers

GLUCAGON RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS FOR THEIR USE

The present invention relates to compounds of general formula (I), wherein ring A, ring B, R1, R2, R3, Z, and L1 are selected independently of each other and are as defined herein, to compositions comprising the compounds, and methods of using the compounds as glucagon receptor antagonists and for the treatment or prevention of type 2 diabetes and conditions related thereto.

Pyrazolyl derivatives, preparation process and intermediates of this process as medicinal products and pharmaceutical compositions containing them

The present invention relates to the novel derivatives of formula (I) in which A is, if it is present, a (C1-C6) alkyl, a (C3-C6) alkenyl, a (C3-C6) alkynyl, a (C3-C7) cycloalkyl or a (C5-C7) cycloalkenyl, R1 is an NR6R7, (C4-C7) azacycloalkyl, (C5-C7) azacycloalkenyl, (C5-C9) azabicycloalkyl or (C5-C9) azabicycloalkenyl group; A-R1 is such that the nitrogen of R1 and the nitrogen in the 1-position of the pyrazole are necessarily separated by at least two carbon atoms, R3 is an H, halogen, OH, SH, NH2, ORc, SRc, SORa, SO2Ra, NHCHO, NRaRb, NHC(O)Ra, NHC(S)Ra or NHSO2Ra, R4 is an aryl or heteroaryl; and R5 is an H, halogen, CF3, CHF2, CH2F, linear or branched (C1-C6) alkyl or (C3-C7) cycloalkyl to their racemates, enantiomers and diastereoisomers and to their mixtures, their tautomers and to their pharmaceutically acceptable salts.