852520-75-3

Upstream product

• 2746-25-0 p-Methoxybenzyl bromide 
• 850166-83-5 6-(4-methoxybenzyloxy)-hex-2-enoic acid ethyl ester 
• 119649-27-3 4-((4-methoxybenzyl)oxy)butanal 
• 119649-45-5 4-(p-methoxybenzyloxy)butan-1-ol 
• 852520-71-9 5-[3-(4-methoxybenzyloxy)-propyl]-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid 
• 852520-70-8 2,3-dihydroxy-6-(4-methoxybenzyloxy)-hexanoic acid ethyl ester 
• 852520-72-0 {5-[3-(4-methoxybenzyloxy)-propyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-methanol 
• 852520-73-1 (4S,5R)-5-[3-(4-Methoxy-benzyloxy)-propyl]-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde 
• 852520-74-2 4-(2,2-dibromovinyl)-5-[3-(4-methoxybenzyloxy)-propyl]-2,2-dimethyl-[1,3]dioxolane 

Downstream Products

• 852520-80-0 tert-butyl-[4-{5-[3-(4-methoxybenzyloxy)-propyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-1-(1-methoxymethoxyheptyl)-but-3-ynyloxy]-dimethylsilane 
• 852520-79-7 1-{5-[3-(4-methoxybenzyloxy)-propyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-5-methoxymethoxy-undec-1-yn-4-ol 

Relevant academic research and scientific papers

Total synthesis of microcarpalide

An efficient, convergent approach for the total synthesis of microcarpalide (1) is described. The synthetic strategy features the Sharpless asymmetric dihydroxylation, regioselective epoxide opening with various nucleophiles such as a lithium acetylide and cuprates derived from the vinyl stannane and the vinyl iodide for the construction of a C7-C8 trans-double bond and Yamaguchi macrolactonization as the key steps.