852574-08-4Relevant academic research and scientific papers
Enantioselective Alkylation at the α-Position of Cyclic Ketones using a Chiral Lithium Amide as a Base in the Presence of Lithium Bromide
Murakata, Masatoshi,Nakajima, Makoto,Koga, Kenji
, p. 1657 - 1658 (2007/10/02)
An efficient enantioselective alkylation reaction at the α-position of cyclic ketones (1, 2) can be realized in up to 92percent enantiomeric excess (e.e) by first forming their lithium enolates using a chiral lithium amide 4 in the presence of lithium bromide, followed by treatment with alkyl halides.
