852608-58-3

Basic information

• Product Name: 7-methoxy-2-(3-methoxy-phenyl)-benzofuran-4-carbaldehyde
• Synonyms: 7-methoxy-2-(3-methoxy-phenyl)-benzofuran-4-carbaldehyde
• CAS NO: 852608-58-3
• Molecular Weight: 282.296
• Mol File: 852608-58-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 7-methoxy-2-(3-methoxy-phenyl)-benzofuran-4-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 7-methoxy-2-(3-methoxy-phenyl)-benzofuran-4-carbaldehyde(852608-58-3)
• EPA Substance Registry System: 7-methoxy-2-(3-methoxy-phenyl)-benzofuran-4-carbaldehyde(852608-58-3)

Safety Data

• Hazardous Substances Data: 852608-58-3(Hazardous Substances Data)

Upstream product

• 768-70-7 1-ethynyl-3-methoxybenzene 
• 138490-94-5 2-iodoisovanillin 
• 35090-65-4 6-bromo-2-hydroxy-3-methoxybenzyl alcohol 
• 20035-41-0 6-bromo-2-hydroxy-3-methoxybenzaldehyde 
• 68-12-2 N,N-dimethyl-formamide 

Relevant articles and documents

Organic transformations catalyzed by palladium nanoparticles on carbon nanomaterials

Abstract: An efficient C–C bond coupling reactions (Suzuki–Miyaura and Glaser) catalyzed by PdO/GO nano-catalyst is presented. In addition, PdO/MWCNT nano-catalyst-mediated domino one-pot synthesis of 2-alkyl/2-aryl benzofurans has been accomplished from 2-iodophenols and terminal alkynes. The formation of benzofurans proceeds through intermolecular Sonogashira reaction followed by intramolecular nucleophilic addition of internal hydroxyl group onto the acetylenic bond. The catalyst PdO/GO has been reused successfully, with nearly no loss of activity up to 5 cycles. Graphical Abstract: : Synopsis: An efficient PdO/GO and PdO/MWCNT nanocatalysts have been developed for C–C coupling reactions like Suzuki and Glaser coupling reactions, multi-catalytic one-pot synthesis of 2-aryl, 2-alkyl benzofurans staring from 2-iodophenols and terminal alkynes. The protocol involves formation of benzofuran derivatives, i.e., Sonogashira reaction followed by 2-ethynyl phenol cyclization. [Figure not available: see fulltext.]

Novel 4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methylbenzofuran derivatives as selective α2C-adrenergic receptor antagonists

The synthesis of a series of 4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methyl-2-arylbenzofuran and 4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methylbenzofuran-2-carboxamide derivatives as novel α2C-adrenergic receptor antagonists are described. Their affinity at three different human α2-adrenergic receptors is reported, and some of these compounds exhibited high affinity for the α2C-adrenergic receptor with high subtype selectivity. Among them, compound 10e has been found to show the anti-l-dopa-induced dyskinetic activity in marmosets. The structure-activity relationship of these compounds is also discussed.