852623-75-7Relevant academic research and scientific papers
Synthesis and biological evaluation of a focused library of beauveriolides
Nagai, Kenichiro,Doi, Takayuki,Ohshiro, Taichi,Sunazuka, Toshiaki,Tomoda, Hiroshi,Takahashi, Takashi,Omura, Satoshi
scheme or table, p. 4397 - 4400 (2009/04/06)
Fungal beauveriolide III (1b), discovered as an inhibitor of lipid droplet accumulation in mouse macrophages and showing antiatherogenic activity in mouse model, consists of l-Phe, l-Ala, d-allo-Ile, and (3S, 4S)-3-hydroxy-4-methyloctanoic acid moieties. A combinatorial library of beauveriolide analogues focusing on l-Ala and d-allo-Ile of 1b was synthesized by combinatorial synthesis. Among them, d-Ala analogues consisting of A{2} improved their solubility, while those with 7{1, 3, 2},7{2, 3, 1}, and 7{2, 3, 2} were 20 times more potent than 1b.
