852655-70-0Relevant articles and documents
The synthesis and biological evaluation of novel series of nitrile-containing fluoroquinolones as antibacterial agents
Murphy, Sean T.,Case, Heather L.,Ellsworth, Edmund,Hagen, Susan,Huband, Michael,Joannides, Themis,Limberakis, Chris,Marotti, Keith R.,Ottolini, Amy M.,Rauckhorst, Mark,Starr, Jeremy,Stier, Michael,Taylor, Clarke,Zhu, Tong,Blaser, Adrian,Denny, William A.,Lu, Guo-Liang,Smaill, Jeff B.,Rivault, Freddy
, p. 2150 - 2155 (2008/02/02)
Several novel series of nitrile-containing fluoroquinolones with weakly basic amines are reported which have reduced potential for hERG (human ether-a-go-go gene) channel inhibition as measured by the dofetilide assay. The new fluoroquinolones are potent
QUINOLONE ANTIBACTERIAL AGENTS
-
Page/Page column 81; 82; 109; 110, (2010/02/12)
Compounds of formula (I) wherein A is formula (II), formula (III) or formula (IV), and B is formula (V), formula (VI), or formula (VII), can be used in a variety of applications including use as antibacterial agents.
ANTIBACTERIAL AMINOQUINAZOLIDINEDIONE DERIVATIVES
-
Page/Page column 110; 111; 137; 138, (2010/02/12)
Compounds of formula (I) wherein: A is Formula (II), Formula (III), or Formula (IV) and B is Formula (V), Formula (VI), or Formula (VII), can be used in a variety of applications including use as antibacterial agents.
