852668-37-2

Upstream product

• 106-50-3 1,4-phenylenediamine 
• 55809-53-5 5-tert-butyl-3-isoxazolyl isocyanate 
• 852668-39-4 1-(5-tert-butyl-isoxazol-3-yl)-3-(4-nitro-phenyl)-urea 

Downstream Products

• 852668-44-1 C₂₀H₂₂N₄O₄S 
• 852668-38-3 C₁₅H₂₀N₄O₂ 
• 1401533-30-9 N-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-4-methylpicolinamide 
• 1347535-38-9 N-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)-5-methylpicolinamide 
• 1401533-33-2 C₃₀H₃₈N₆O₅ 
• 1401533-34-3 N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-((1-ethylpiperidin-4-yl)methyl)picolinamide 
• 1351522-46-7 5-bromo-N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)picolinamide 
• 1351521-72-6 N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(1-tert-butylpiperidin-4-yloxy)picolinamide 
• 1351521-70-4 N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(1-cyclopropylpiperidin-4-yloxy)picolinamide 
• 1351521-68-0 N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(1,2,2,6,6-pentamethylpiperidin-4-yloxy)picolinamide 
• 1351522-04-7 N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(1-ethyl-2,2,6,6-tetramethylpiperidin-4-yloxy)picolinamide 
• 1351522-28-5 N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(2,2,6,6-tetramethylpiperidin-4-yloxy)picolinamide 
• 1351522-39-8 tert-butyl 4-(2-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenylcarbamoyl)pyridin-4-yloxy)piperidine-1-carboxylate 
• 1351521-37-3 N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(4-methylpiperazin-1-yl)picolinamide 

Relevant academic research and scientific papers

Arylcarboxyamino-substituted diaryl ureas as potent and selective FLT3 inhibitors

A series of diaryl ureas with an amide substitution at the 4-position was prepared and found to be potent and selective FLT3 inhibitors with good oral bioavailability and efficacy in a tumor xenograft model.

UREA DERIVATIVES AS KINASE MODULATORS

The invention provides methods and compositions for treating conditions mediated by various kinases wherein derivatives of urea compounds are employed. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.