852690-13-2Relevant academic research and scientific papers
Novel N1-substituted 1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside reverse transcriptase inhibitors
Monforte, Anna-Maria,Rao, Angela,Logoteta, Patrizia,Ferro, Stefania,De Luca, Laura,Barreca, Maria Letizia,Iraci, Nunzio,Maga, Giovanni,De Clercq, Erik,Pannecouque, Christophe,Chimirri, Alba
, p. 7429 - 7435 (2008/12/23)
Several N1-substituted 1,3-dihydro-2H-benzimidazol-2-ones were synthesized and evaluated as anti-HIV agents. Some of them proved to be highly effective in inhibiting HIV-1 replication at nanomolar concentration as potent non-nucleoside HIV-1 RT
Computational strategies in discovering novel non-nucleoside inhibitors of HIV-1 RT
Barreca, Maria Letizia,Rao, Angela,De Luca, Laura,Zappalà, Maria,Monforte, Anna-Maria,Maga, Giovanni,Pannecouque, Christophe,Balzarini, Jan,De Clercq, Erik,Chimirri, Alba,Monforte, Pietro
, p. 3433 - 3437 (2007/10/03)
A three-dimensional common feature pharmacophore model was developed using the X-ray structure of RT/non-nucleoside inhibitor (NNRTI) complexes. Starting from the pharmacophore hypothesis and the structure of the lead compound TBZ, new NNRTIs were designe
