852720-32-2Relevant academic research and scientific papers
Novel P-stereogenic PCP pincer-aryl ruthenium(II) complexes and their use in the asymmetric hydrogen transfer reaction of acetophenone
Medici, Serenella,Gagliardo, Marcella,Williams, Scott B.,Chase, Preston A.,Gladiali, Serafino,Lutz, Martin,Spek, Anthony L.,Van Klink, Gerard P.M.,Van Koten, Gerard
, p. 694 - 705 (2007/10/03)
Achiral P-donor pincer-aryl ruthenium complexes ([RuCl(PCP)(PPh 3)]) 4c,d were synthesized via transcyclometalation reactions by mixing equivalent amounts of [1,3-phenylenebis(methylene)] bis[diisopropylphosphine] (2c) or [1,3-phenylenebis(methylene)] bis[diphenylphosphine] (2d) and the N-donor pincer-aryl complex [RuCl{2,6-(Me2NCH2)2C6H 3}(PPh3)], (3; Scheme 2). The same synthetic procedure was successfully applied for the preparation of novel chiral P-donor pincer-aryl ruthenium complexes [RuCl(P*CP*)(PPh3)] 4a,b by reacting P-stereogenic pincer-arenes (S,S)-[1,3-phenylenebis(methylene)]bis[(alkyl) (phenyl)phosphines] 2a,b (alkyl = iPr or tBu, P*CHP*) and the complex [RuCl{2,6-(Me2NCH 2)2C6H3}(PPh3)], (3; Scheme 3). The crystal structures of achiral [RuCl(iPr,iPrPCP) (PPh3)] 4c and of chiral (S,S)-[RuCl-(tBu,PhPCP)(PPh 3)] 4a were determined by X-ray diffraction (Fig. 3). Achiral [RuCl(PCP)(PPh3)] complexes and chiral [RuCl(P*CP*) (PPh3)] complexes were tested as catalyst in the H-transfer reduction of acetophenone with propan-2-ol. With the chiral complexes, a modest enantioselectivity was obtained.
