85277-61-8

Upstream product

• 32864-38-3 tert-Butyl ethyl malonate 
• 623-12-1 4-chloromethoxybenzene 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 33155-61-2 tert-butyl 2-(4-methoxyphenyl)acetate 
• 541-41-3 chloroformic acid ethyl ester 

Downstream Products

• 85277-72-1 1-tert-butyl 3-ethyl 2-(difluoromethyl)-2-(4-methoxyphenyl)malonate 
• 85277-94-7 (E)-3-fluoro-2-(4-methoxyphenyl)prop-2-en-1-ol 
• 85277-85-6 (E)-ethyl 3-fluoro-2-(4-methoxyphenyl)acrylate 
• 85278-03-1 (E)-1-Fluoro-2-(4'-methoxy)phenyl-3-phthalimidopropene 
• 85278-11-1 (E)-3-Fluoro-2-(4-methoxy-phenyl)-allylamine; hydrochloride 
• 104-01-8 4-Methoxyphenylacetic acid 

Relevant academic research and scientific papers

Method for synthesizing p-methoxyphenylacetic acid

The invention discloses a method for synthesizing p-methoxyphenylacetic acid. The method comprises the following steps: adding malonate, alkali and p-methoxy halobenzene in a solvent, enabling the p-methoxy halobenzene and the malonate to perform alkylation reaction under the alkali condition, adding water to perform quenching reaction after the reaction is finished, directly acidizing and heatingto perform the decarboxylation hydrolysis reaction after concentrating out most solvent, and then cooling to crystallize, filter and dry, namely obtaining the p-methoxyphenylacetic acid. The method disclosed by the invention has the following advantages: 1, the raw materials used by the method of the invention are easier to obtain and convenient for storing, the raw material and operation cost are greatly reduced; 2, the method disclosed by the invention is less in reaction step, the intermediate reaction process is easy to control and easy for scale production; and 3, the three waste (wastewater, waste solid and waste gas) yield is less, the environment pollution is reduced, and the ecological environment is protected. And meanwhile, the prepared product is high in purity, and the purity can achieve 99% or more; the yield is high and can achieve 95% or more.

NEW ARYLALKENYLPROPARGYLAMINE DERIVATIVES EXHIBITING NEUROPROTECTIVE ACTION FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

The invention relates to novel arylalkenylpropargylamine derivatives of general formula (I) or enantiomers or diastereomers thereof or salts, optionally pharmaceutically acceptable salts, or solvates of any of these. The compounds can be used in treating or preventing a disease or condition in a mammal related to monoamine oxidase dysfunction, especially in neurodegenerative diseases, e.g. Parkinson's disease, Alzheimer's disease or Huntington's disease.

Enzyme-activated irreversible inhibitors of monoamine oxidase: Phenylallylamine structure-activity relationships

Seventeen 2-aryl-3-haloallylamine derivatives were prepared and evaluated as inhibitors of monoamine oxidase (MAO, EC 1.4.3.4). The synthesis of these compounds was achieved from either α-methylstyrene or ring-substituted phenylacetic acid derivatives. Wi

Allyl amine MAO inhibitors

Compounds of the formula STR1 wherein: R is phenyl, phenyl monosubstituted, disubstituted, or trisubstituted by (C1 -C8) alkyl, (C1 -C8)alkoxy, hydroxy, chlorine, bromine, iodine, fluorine, trifluoromethyl, nitr