85278-38-2

Upstream product

• 85278-37-1 (3,3-Difluoro-2-phenyl-allyl)-carbamic acid tert-butyl ester 
• 85278-36-0 2-phenyl-3,3-difluoroallylamine 
• 85278-30-4 ethyl 2-(tert-butoxycarbonyl)-2-(bromodifluoromethyl)phenylacetate 
• 85278-35-9 1,1-difluoro-2-phenyl-3-phthalimidopropene 
• 85277-62-9 ethyl 2-(tert-butoxycarbonyl)phenylacetate 
• 85278-32-6 ethyl 2-phenyl-3,3-difluoroacrylate 
• 85278-33-7 3,3-difluoro-2-phenyl-2-propen-1-ol 
• 16537-09-0 t-butyl phenylacetate 

Relevant academic research and scientific papers

Chemodivergent and Stereoselective Construction of gem-Difluoroallylic Amines from Masked Difluorodiazo Reagents

We report a general and efficient approach to construct achiral and chiral gem-difluoroallylic amines from a masked difluorodiazo reagent (PhSO2CF2CHN2) and readily available imines. This facile protocol takes advantage of the phenylsulfonyl and diazo moieties as efficient activating and directing groups to assist difluoroalkyl incorporation and facilitate the chemodivergent and stereoselective formation of gem-difluoroallylic amines.

Inactivation of bovine plasma amine oxidase by haloallylamines

Various 2- and 3-haloallylamines were synthesized and evaluated as inhibitors of the quinone-dependent bovine plasma amine oxidase (BPAO). 3-Haloallylamines, which were previously found to be good inhibitors of the flavin-dependent mitochondrial monoamine