852802-53-0Relevant academic research and scientific papers
Identification of a novel series of benzimidazoles as potent and selective antagonists of the human melanocortin-4 receptor
Poitout, Lydie,Brault, Valerie,Sackur, Carole,Bernetiere, Sonia,Camara, Jose,Plas, Pascale,Roubert, Pierre
, p. 4464 - 4470 (2008/03/11)
A novel series of benzimidazoles was identified and optimized, leading to the discovery of potent and selective antagonists of the human melanocortin-4 receptor. In addition, compound 5i was shown to cross the blood-brain barrier after intravenous dosing
Novel benzimidazole and imidazopyridine derivatives and use thereof as a medicament
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Page/Page column 22, (2010/11/25)
The invention relates to novel benzimidazole and imidazopyridine derivatives having general formula (I), which have a good affinity with certain sub-types of melanocortin receptors, particularly MC4 receptors. Said derivatives are particularly suitable for the treatment of pathological states and diseases involving one or more melanocortin receptors. The invention also relates to pharmaceutical compositions containing said products.
