85285-37-6Relevant academic research and scientific papers
O -iodoxybenzoic acid mediated oxidative desulfurization initiated domino reactions for synthesis of azoles
Chaudhari, Pramod S.,Pathare, Sagar P.,Akamanchi, Krishnacharaya G.
, p. 3716 - 3723 (2012)
A systematic exploration of thiophilic ability of o-iodoxybenzoic acid (IBX) for oxidative desulfurization to trigger domino reactions leading to new methodologies for synthesis of different azoles is described. A variety of highly substituted oxadiazoles, thiadiazoles, triazoles, and tetrazoles have been successfully synthesized in good to excellent yields, starting from readily accessible thiosemicarbazides, bis-diarylthiourea, 1,3-disubtituted thiourea, and thioamides.
A general synthetic method for the formation of substituted 5-aminotetrazoles from thioureas: a strategy for diversity amplification.
Batey,Powell
, p. 3237 - 3240 (2007/10/03)
A general method for the synthesis of 5-aminotetrazoles is outlined using the mercury(II)-promoted attack of azide anion on a thiourea. The reaction proceeds through a guanyl azide intermediate, which undergoes electrocyclization to the tetrazole. The method is high yielding and provides access to mono-, di-, and trisubstituted 5-aminotetrazoles, targets of potential interest for combinatorial library development.
