852852-85-8Relevant academic research and scientific papers
Design and synthesis of potent hydroxamate inhibitors with increased selectivity within the gelatinase family
Zapico, Jos Mara,Puckowska, Anna,Filipiak, Kamila,Coderch, Claire,De Pascual-Teresa, Beatriz,Ramos, Ana
, p. 142 - 156 (2014)
MMP-2 is a validated target for the development of anticancer agents. Herein we describe the synthesis of a new series of potent phenylalanine derived hydroxamates, with increased MMP-2/MMP-9 selectivity compared to analogous hydroxamates described previously. Docking and molecular dynamics experiments have been used to account for this selectivity, and to clarify the role of the triazole ring in the binding process. This journal is
Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles
Montgomery, Thomas D.,Rawal, Viresh H.
supporting information, p. 740 - 743 (2016/03/01)
We report here a novel method for the modular synthesis of highly substituted piperazines and related bis-nitrogen heterocycles via a palladium-catalyzed cyclization reaction. The process couples two of the carbons of a propargyl unit with various diamine components to provide nitrogen heterocycles in generally good to excellent yields and high regio- and stereochemical control. (Chemical Equation Presented).
N-methylation of peptides on selected positions during the elongation of the peptide chain in solution phase
Di Gioia, M. Luisa,Leggio, Antonella,Liguori, Angelo
, p. 3892 - 3897 (2007/10/03)
An efficient and general solution-phase method for the site-specific N-methylation of peptides has been developed. This novel procedure involves synthesis of N-nosyl protected peptides and their subsequent N-methylation with diazomethane. Its efficiency w
