852853-21-5

Upstream product

• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 72-18-4 L-valine 
• 270073-00-2 3-methyl-2-(4-nitrophenylsulphonamido)butanoic acid 

Downstream Products

• 945014-92-6 N-methyl-N-nosyl-L-valyldiazomethane 
• 852853-10-2 N-(N-(N-nosyl-L-valyl)-N-methyl-L-phenylalanyl)-L-alanine methyl ester 
• 852853-11-3 N-(N-(N-nosyl-L-valyl)-N-methyl-D-phenylalanyl)-L-alanine methyl ester 
• 852853-12-4 N-(N-(N-nosyl-L-valyl)-N-methyl-L-isoleucyl)-L-alanine methyl ester 

Relevant academic research and scientific papers

N-methylation of peptides on selected positions during the elongation of the peptide chain in solution phase

An efficient and general solution-phase method for the site-specific N-methylation of peptides has been developed. This novel procedure involves synthesis of N-nosyl protected peptides and their subsequent N-methylation with diazomethane. Its efficiency w

Synthesis and anticancer activity of the proposed structure of caldoramide, an N-peptidyltetramate from the cyanobacterium Caldora penicillata

The structure proposed in the literature for caldoramide, a formal pentapeptide metabolite of the marine cyanobacterium Caldora penicillata, was synthesised in 12 steps and 16% yield (longest linear sequence from isoleucine) following the strategy of a stepwise consecutive extension of an N-oligopeptidyl chain on a tetramate anchor. The synthetic product differed from the natural isolate in optical rotation, some NMR data, and cytotoxicities. Its antiproliferative effect on three human cancer cell lines was distinctly lower than that of related dolastatin 10 and belamide A.

N-methyl-N-nosyl-β3-amino acids

(Chemical Equation Presented) N-Methyl-β3-amino acids are important building blocks in the synthesis of biologically active molecules. A very simple and efficient approach to transform natural α-amino acids into their corresponding N-methyl-βs