852853-22-6

Upstream product

• 673-06-3 D-(R)-phenylalanine 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 

Downstream Products

• 852852-91-6 N-(N-nosyl-D-phenylalanyl)-L-alanine methyl ester 
• 852853-04-4 N-(N-methyl-N-nosyl-D-phenylalanyl)-L-alanine methyl ester 
• 852853-11-3 N-(N-(N-nosyl-L-valyl)-N-methyl-D-phenylalanyl)-L-alanine methyl ester 

Relevant academic research and scientific papers

Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles

We report here a novel method for the modular synthesis of highly substituted piperazines and related bis-nitrogen heterocycles via a palladium-catalyzed cyclization reaction. The process couples two of the carbons of a propargyl unit with various diamine components to provide nitrogen heterocycles in generally good to excellent yields and high regio- and stereochemical control. (Chemical Equation Presented).

N-methylation of peptides on selected positions during the elongation of the peptide chain in solution phase

An efficient and general solution-phase method for the site-specific N-methylation of peptides has been developed. This novel procedure involves synthesis of N-nosyl protected peptides and their subsequent N-methylation with diazomethane. Its efficiency w