852854-39-8 Usage
General Description
2-(Trifluoromethyl)-4-thiazolemethanamine is a chemical compound with the molecular formula C5H5F3N2S. It is a thiazole derivative and features a trifluoromethyl group attached to the second carbon atom of the thiazole ring. 2-(Trifluoromethyl)-4-thiazolemethanamine has potential applications in medicinal chemistry and drug development due to its structural features, which could make it suitable for use as a building block in the synthesis of pharmaceuticals. Additionally, the trifluoromethyl group is known to enhance the biological activity of molecules, making this compound of interest for further research and development. It is important to handle this chemical with care and follow proper safety protocols due to potential health hazards associated with its use.
Check Digit Verification of cas no
The CAS Registry Mumber 852854-39-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,2,8,5 and 4 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 852854-39:
(8*8)+(7*5)+(6*2)+(5*8)+(4*5)+(3*4)+(2*3)+(1*9)=198
198 % 10 = 8
So 852854-39-8 is a valid CAS Registry Number.
InChI:InChI=1/C5H5F3N2S/c6-5(7,8)4-10-3(1-9)2-11-4/h2H,1,9H2
852854-39-8Relevant articles and documents
Zirconium-hydride-catalyzed site-selective hydroboration of amides for the synthesis of amines: Mechanism, scope, and application
Han, Bo,Jiao, Haijun,Wu, Lipeng,Zhang, Jiong
, p. 2059 - 2067 (2021/09/02)
Developing mild and efficient catalytic methods for the selective synthesis of amines is a longstanding research objective. In this respect, catalytic deoxygenative amide reduction has proven to be promising but challenging, as this approach necessitates selective C–O bond cleavage. Herein, we report the selective hydroboration of primary, secondary, and tertiary amides at room temperature catalyzed by an earth-abundant-metal catalyst, Zr-H, for accessing diverse amines. Various readily reducible functional groups, such as esters, alkynes, and alkenes, were well tolerated. Furthermore, the methodology was extended to the synthesis of bio- and drug-derived amines. Detailed mechanistic studies revealed a reaction pathway entailing aldehyde and amido complex formation via an unusual C–N bond cleavage-reformation process, followed by C–O bond cleavage.
