852854-39-8

Usage

Uses

Used in Medicinal Chemistry:
2-(Trifluoromethyl)-4-thiazolemethanamine is used as a building block in the synthesis of pharmaceuticals for its potential to contribute to the development of new drugs. Its structural features, including the trifluoromethyl group, may enhance the biological activity of the resulting compounds, making it a valuable component in drug discovery and design.
Used in Drug Development:
In the pharmaceutical industry, 2-(Trifluoromethyl)-4-thiazolemethanamine is used as a precursor in the development of new drugs. Its unique structure and the trifluoromethyl group's ability to improve biological activity make it a promising candidate for creating innovative therapeutic agents. Researchers and chemists in the drug development field may utilize 2-(Trifluoromethyl)-4-thiazolemethanamine to explore its potential in treating various diseases and conditions.

InChI:InChI=1/C5H5F3N2S/c6-5(7,8)4-10-3(1-9)2-11-4/h2H,1,9H2

Upstream product

• 852854-38-7 4-(bromomethyl)-2-(trifluoromethyl)thiazole 

Relevant academic research and scientific papers

Zirconium-hydride-catalyzed site-selective hydroboration of amides for the synthesis of amines: Mechanism, scope, and application

Developing mild and efficient catalytic methods for the selective synthesis of amines is a longstanding research objective. In this respect, catalytic deoxygenative amide reduction has proven to be promising but challenging, as this approach necessitates selective C–O bond cleavage. Herein, we report the selective hydroboration of primary, secondary, and tertiary amides at room temperature catalyzed by an earth-abundant-metal catalyst, Zr-H, for accessing diverse amines. Various readily reducible functional groups, such as esters, alkynes, and alkenes, were well tolerated. Furthermore, the methodology was extended to the synthesis of bio- and drug-derived amines. Detailed mechanistic studies revealed a reaction pathway entailing aldehyde and amido complex formation via an unusual C–N bond cleavage-reformation process, followed by C–O bond cleavage.

BICYCLIC PYRIMIDIN-4-(3H)-ONES AND ANALOGUES AND DERIVATIVES THEREOF WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1)

Compounds of formula (I); which are useful as therapeutic compounds, particularly in the treatment of pain and other conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VR1).