85288-36-4Relevant academic research and scientific papers
Method of biocatalytically synthesizing 4-substituted oxazolidinone compound
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Paragraph 0066; 0067; 0068; 0069, (2019/04/27)
The invention discloses a biocatalytic technology of synthesizing a 4-substituted oxazolidinone compound by carrying out a reaction on a halohydrin dehalogenase catalyzed epoxy compound and cyanate. The reaction takes the epoxy compound as a primer, cyanate as a nucleophilic ring opening reagent and halohydrin dehalogenase which is originated from an Ilumatobacter coccineus strain and has high alpha-offensive ring opening area selectivity as a biocatalyst. The reaction is carried out in a water phase and is mild in reaction condition. The invention is the biocatalytic method of catalyzing theepoxy compound to synthesize the 4-substituted oxazolidinone compound by using the halohydrin dehalogenase for the first time. The method has a wide application prospect in design of an oxazolidinonedrug and green manufacturing aspect thereof.
THE INTRAMOLECULAR CHEMISTRY OF BENZYL AND PHENETHYL AZIDOFORMATES
Meth-Cohn, Otto,Patel, Dalpat,Rhouati, Salah
, p. 5085 - 5088 (2007/10/02)
Benzyl azidoformates yield one of a variety of products on spray pyrolysis dependent upon substitution, including oxazoloazepines, their syn or anti dimers, their dimers, a benzoxazinone or aryl isocyanate; the phenethyl analogues give stable oxazinoazepines.
