85288-36-4

Basic information

• Product Name: 4-(4-tert-butylphenyl)-oxazolidine-2-one
• Synonyms: 4-(4-tert-butylphenyl)-oxazolidine-2-one
• CAS NO: 85288-36-4
• Molecular Weight: 219.283
• Mol File: 85288-36-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(4-tert-butylphenyl)-oxazolidine-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-tert-butylphenyl)-oxazolidine-2-one(85288-36-4)
• EPA Substance Registry System: 4-(4-tert-butylphenyl)-oxazolidine-2-one(85288-36-4)

Safety Data

• Hazardous Substances Data: 85288-36-4(Hazardous Substances Data)

Upstream product

• 917-61-3 sodium isocyanate 
• 2783-28-0 4-tert-butylphenylethylene oxide 

Relevant articles and documents

Method of biocatalytically synthesizing 4-substituted oxazolidinone compound

The invention discloses a biocatalytic technology of synthesizing a 4-substituted oxazolidinone compound by carrying out a reaction on a halohydrin dehalogenase catalyzed epoxy compound and cyanate. The reaction takes the epoxy compound as a primer, cyanate as a nucleophilic ring opening reagent and halohydrin dehalogenase which is originated from an Ilumatobacter coccineus strain and has high alpha-offensive ring opening area selectivity as a biocatalyst. The reaction is carried out in a water phase and is mild in reaction condition. The invention is the biocatalytic method of catalyzing theepoxy compound to synthesize the 4-substituted oxazolidinone compound by using the halohydrin dehalogenase for the first time. The method has a wide application prospect in design of an oxazolidinonedrug and green manufacturing aspect thereof.