85290-54-6Relevant academic research and scientific papers
Rapid reduction of heteroaromatic nitro groups using catalytic transfer hydrogenation with microwave heating
Quinn, John F.,Bryant, Cole E.,Golden, Kathryn C.,Gregg, Brian T.
, p. 786 - 789 (2010)
A method for the rapid, safe reduction of heteroaromatic and aromatic nitro groups to amines is described using catalytic transfer hydrogenation under microwave heating conditions. Commonly available Pd/C or Pt/C catalyst is extremely effective with 1,4-cyclohexadiene as the hydrogen transfer source. In the case of substrates containing potentially labile aromatic halogens, Pt/C is effective and results in little or no dehalogenation. In general, the reactions are complete within 5 min at 120 °C.
