85290-78-4

Basic information

• Product Name: ethyl-3-methyl-1H-pyrazole-4-carboxylate
• Synonyms: ethyl-3-methyl-1H-pyrazole-4-carboxylate;Ethyl5-methylpyrazole-4-carboxylate;5-methyl-1H-pyrazole-4-carboxylic acid ethyl ester;3-Methyl-1H-pyrazole-4-carboxylic Acid Ethyl Ester;NSC 19454;4-(Ethoxycarbonyl)-5-methyl-1H-pyrazole, Ethyl 3-methyl-1H-pyrazole-4-carboxylate, 4-(Ethoxycarbonyl)-3-methyl-1H-pyrazole;H-Pyrazole-4-carboxylicacid, 3-methyl-, ethyl ester;3-Methylpyrazole-4-carboxylate
• CAS NO: 85290-78-4
• Molecular Formula: C₇H₁₀N₂O₂
• Molecular Weight: 154.1665
• Product Categories: Nucleotides and Nucleosides;Bases & Related Reagents;Nucleotides
• Mol File: 85290-78-4.mol
• Article Data: 10

Chemical Properties

• Melting Point: 49-52°C
• Boiling Point: 280.6±20.0 °C(Predicted)
• Appearance: /
• Density: 1.171±0.06 g/cm3(Predicted)
• Storage Temp.: Room temperature.
• PKA: 12.26±0.50(Predicted)
• CAS DataBase Reference: ethyl-3-methyl-1H-pyrazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl-3-methyl-1H-pyrazole-4-carboxylate(85290-78-4)
• EPA Substance Registry System: ethyl-3-methyl-1H-pyrazole-4-carboxylate(85290-78-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 85290-78-4(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

Shows systemic antifungal activity accompanied by high levels of phytotoxicity

Upstream product

• 64-17-5 ethanol 
• 40704-11-8 3-methyl-1H-pyrazole-4-carboxylic acid 
• 3788-94-1 2-ethoxymethylene-3-oxobutanoic acid ethyl ester 
• 134653-70-6 α-acetyl-α-(dimethylaminomethylene)acetic acid,ethyl ester 
• 141-97-9 ethyl acetoacetate 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 3724-43-4 Vilsmeier reagent 
• 49836-24-0 (E)-2-(ethoxymethylene)-3-oxobutanoic acid ethyl ester 

Downstream Products

• 1313195-84-4 N-(2-hydroxyethyl)-3-methyl-1-(2-(3-(trifluoromethyl)benzyl)-1-benzothiophen-7-yl)-1H-pyrazole-4-carboxamide 
• 1313196-05-2 5-methyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxylic acid 
• 1313196-06-3 3-methyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboylic acid 
• 1313196-03-0 ethyl 5-methyl-1-(2-(3-(trifluoromethyl)benzyl)-1-benzothiophen-7-yl)-1Hpyrazole-4-carboxylate 
• 1313196-04-1 ethyl 3-methyl-1-(2-(3-(trifluoromethyl)benzyl)-1-benzothiophen-7-yl)-1H-pyrazole-4-carboxylate 
• 113100-61-1 1,3-dimethyl-1H-pyrazole-4-carboxylic acid chloride 
• 78703-53-4 1,3-dimethyl-1H-pyrazole-4-carboxylic acid 
• 1313195-83-3 N-(2-methoxyethyl)-3-methyl-1-(2-(3-(trifluoromethyl)benzyl)-1-benzothiophen-7-yl)-1H-pyrazole-4-carboxamide 
• 1313196-93-8 N-(2-methoxyethyl)-5-methyl-1-(2-(3-(trifluoromethyl)benzyl)-1-benzothiophen-7-yl)-1H-pyrazole-4-carboxamide 
• 1307313-17-2 1-[2-[4-[(2-chloro-4,4-difluoro-4,5-dihydrospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)methyl]-3-methylpyrazol-1-yl]-3-fluorophenyl]-N,N-dimethylmethanamine (L)-tartrate 
• 1307313-39-8 1-[2-[4-[(2-chlorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)methyl]-3-methylpyrazol-1-yl]-3-fluorophenyl]-N,N-dimethylmethanamine (L)-tartrate 

Relevant articles and documents

An efficient synthesis of 1-H-pyrazole-4-carboxylic acid esters with Vilsmeier reagent under neat conditions

A convenient, solvent-free Vilsmeier reagent is experimented under neat condition (both thermal and microwave conditions). An efficient method for the synthesis of various substituted 1H-pyrazole-4-carboxylic acid esters is reported.

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.

Synthesis and antifungal activity of the derivatives of novel pyrazole carboxamide and isoxazolol pyrazole carboxylate

A series of pyrazole carboxamide and isoxazolol pyrazole carboxylate derivatives were designed and synthesized in this study. The structures of the compounds were elucidated based on spectral data (infrared, proton nuclear magnetic resonance and mass spectroscopy). Then, all of the compounds were bioassayed in vitro against four types of phytopathogenic fungi (Alternaria porri, Marssonina coronaria, Cercospora petroselini and Rhizoctonia solani ) using the mycelium growth inhibition method. The results showed that some of the synthesized pyrazole carboxamides displayed notable antifungal activity. The isoxazole pyrazole carboxylate 7ai exhibited significant antifungal activity against R. solani, with an EC50 value of 0.37 μg/mL. Nonetheless, this value was lower than that of the commercial fungicide, carbendazol.