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852918-02-6

3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide, also known as TCN 201, is a novel NMDA receptor antagonist that selectively targets NR2A-containing receptors over NR2B-containing receptors. It is a chemical compound with potential applications in various industries.

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  • 852918-02-6 Structure

  • Basic information

    1. Product Name: 3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide
    2. Synonyms: 3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide;TCN 201;N-(4-(2-benzoylhydrazinecarbonyl)benzyl)-3-chloro-4-fluorobenzenesulfonaMide;4-[[[(3-Chloro-4-fluorophenyl)sulfonyl]aMino]Methyl]benzoic Acid 2-Benzoylhydrazide;TCN 201-d5;TCN-201 N-(4-(2-benzoylhydrazinecarbonyl)benzyl)-3-chloro-4- fluorobenzenesulfonaMide;3-Chloro-4-fluoro-N-[(4-{[2-(phenylcarbonyl)hydrazino]carbonyl}phenyl)methyl]benzenesulfonamide;N-[[4-(benzamidocarbamoyl)phenyl]methyl]-3-chloro-4-fluorobenzenesulfonamide
    3. CAS NO:852918-02-6
    4. Molecular Formula: C21H17ClFN3O4S
    5. Molecular Weight: 461.8937832
    6. EINECS: N/A
    7. Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
    8. Mol File: 852918-02-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: white to beige/
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: Store at +4°C
    8. Solubility: DMSO: soluble5mg/mL (clear solution)
    9. CAS DataBase Reference: 3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide(852918-02-6)
    11. EPA Substance Registry System: 3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide(852918-02-6)

  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 22-36/37/38
    3. Safety Statements: 26-36/37/39
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 852918-02-6(Hazardous Substances Data)

852918-02-6 Usage

Uses

Used in Pharmaceutical Industry:
3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide is used as a pharmaceutical agent for its selective antagonistic activity on NMDA receptors, specifically targeting NR2A-containing receptors. This selective targeting may provide therapeutic benefits in treating neurological disorders associated with the dysregulation of NMDA receptors.
Used in Research Applications:
Labelled TCN 201 (T012550) is used as a research tool for studying the role of NMDA receptors, particularly the NR2A subtype, in various biological processes and disease mechanisms. The selective binding of TCN 201 to NR2A-containing receptors allows researchers to investigate the specific functions and interactions of this receptor subtype in cellular and molecular studies.

Biochem/physiol Actions

TCN-201 is a sulphonamide derivative, that negatively modulates glycine binding to the GluN1 (glutamate receptor subunit) subunit of the receptor.

Check Digit Verification of cas no

The CAS Registry Mumber 852918-02-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,2,9,1 and 8 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 852918-02:
(8*8)+(7*5)+(6*2)+(5*9)+(4*1)+(3*8)+(2*0)+(1*2)=186
186 % 10 = 6
So 852918-02-6 is a valid CAS Registry Number.

852918-02-6 Well-known Company Product Price

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  • (Code)Product description
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  • Sigma

  • (SML0416)  TCN-201  ≥98% (HPLC)

  • 852918-02-6

  • SML0416-5MG

  • 1,077.57CNY

  • Detail

  • Sigma

  • (SML0416)  TCN-201  ≥98% (HPLC)

  • 852918-02-6

  • SML0416-25MG

  • 4,351.23CNY

  • Detail

852918-02-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name N-[[4-(benzamidocarbamoyl)phenyl]methyl]-3-chloro-4-fluorobenzenesulfonamide

1.2 Other means of identification

Product number -
Other names TCN 201

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:852918-02-6 SDS

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