852945-22-3Relevant academic research and scientific papers
A one-pot synthesis of doubly unsaturated trifluoromethyl amines: Easy access to CF3-substituted piperidines
Magueur, Guillaume,Legros, Julien,Meyer, Franck,Ourevitch, Michele,Crousse, Benoit,Bonnet-Delpon, Daniele
, p. 1258 - 1265 (2007/10/03)
A straightforward route to trifluoromethyl analogs of piperidines is described. These syntheses involve a Barbier-type allylation reaction of trifluoroacetaldimines, followed by N-allylation (one-pot), and ring-closing metathesis. An efficient asymmetric
